Factor X binding to endothelial cell protein C receptor: comparison with factor VIIa and activated protein C.

@article{Sen2011FactorXB,
  title={Factor X binding to endothelial cell protein C receptor: comparison with factor VIIa and activated protein C.},
  author={Prosenjit Sen and Ramesh K Nayak and Curtis A Clark and Ramakrishnan Gopalakrishnan and Charles T. Esmon and Usha R Pendurthi and L Vijaya Mohan Rao},
  journal={Blood},
  year={2011},
  volume={118 9},
  pages={2635-6}
}
Endothelial cell protein C receptor (EPCR) is the cellular receptor for protein C (PC) and activated protein C (APC). Studies from our laboratory1 and others2,3 have shown that FVII/FVIIa also binds to EPCR in a true-ligand fashion. Recently, it has been suggested that FX4 and FXa5 can bind to EPCR and these interactions may play a role in regulating TF-FVIIa-FXa– or FXa-mediated cell signaling via activation of protease activated receptors (PARs). This reported observation that FX/FXa binds to… CONTINUE READING