Factor VIIa-tissue factor: functional importance of protein-membrane interactions.

@article{Morrissey1997FactorVF,
  title={Factor VIIa-tissue factor: functional importance of protein-membrane interactions.},
  author={James H Morrissey and Pierre F. Neuenschwander and Qiuhua Huang and Christine D. McCallum and Bangying Su and Arthur E. Johnson},
  journal={Thrombosis and haemostasis},
  year={1997},
  volume={78 1},
  pages={112-6}
}
The first enzyme in the blood clotting cascade consists of two distinct protein subunits: a catalytic subunit (factor VIIa; FVIIa) and an essential regulatory subunit (tissue factor; TF). FVIIa is a soluble plasma protease, while TF is a cell-surface, integral-membrane protein. The recently reported X-ray crystal structure of the complex of FVIIa and the isolated extracellular domain of TF has provided important insights into the protein-protein interactions that bind these two subunits… CONTINUE READING