Factor VIIa interaction with tissue factor and endothelial cell protein C receptor on cell surfaces.

@article{Pendurthi2008FactorVI,
  title={Factor VIIa interaction with tissue factor and endothelial cell protein C receptor on cell surfaces.},
  author={Usha R Pendurthi and L Vijaya Mohan Rao},
  journal={Seminars in hematology},
  year={2008},
  volume={45 2 Suppl 1},
  pages={S21-4}
}
Factor VIIa (FVIIa) is the enzyme that triggers activation of the clotting cascade that eventually leads to fibrin deposition and platelet activation. Association of FVIIa with its cellular receptor, tissue factor (TF), which greatly increases FVIIa enzymatic activity, is essential for the effective initiation of the coagulation pathway. FVIIa also… CONTINUE READING