Factor VIIa binding to endothelial cell protein C receptor protects vascular barrier integrity in vivo.

@article{Sundaram2014FactorVB,
  title={Factor VIIa binding to endothelial cell protein C receptor protects vascular barrier integrity in vivo.},
  author={Jagan Sundaram and Shiva Keshava and Ramakrishnan Gopalakrishnan and Charles T. Esmon and Usha R Pendurthi and L Vijaya Mohan Rao},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2014},
  volume={12 5},
  pages={690-700}
}
BACKGROUND Recent studies have shown that factor VIIa binds to endothelial cell protein C receptor(EPCR), a cellular receptor for protein C and activated protein C. At present, the physiologic significance of FVIIa interaction with EPCR in vivo remains unclear. OBJECTIVE To investigate whether exogenously administered FVIIa, by binding to EPCR, induces a… CONTINUE READING