Factor VIII-related antigen in human blood platelets: localization and release by thrombin and collagen.

@article{Zucker1979FactorVA,
  title={Factor VIII-related antigen in human blood platelets: localization and release by thrombin and collagen.},
  author={Marjorie B. Zucker and M. Johan Broekman and Karen L. Kaplan},
  journal={The Journal of laboratory and clinical medicine},
  year={1979},
  volume={94 5},
  pages={675-82}
}
Human platelets contain 0.61 +/- 0.06 (S.E.) U of VIIIR:Ag per 10(9) platelets or about 25% of the circulating antigen in whole blood. Assay of subcellular fractions obtained by sucrose density-gradient centrifugation of disrupted platelets indicates that over 85% of the VIIIR:Ag is in the alpha granule fraction with other nonenzymatic proteins which can be… CONTINUE READING