Factor VIII related antigen as an endothelial cell marker in benign and malignant diseases

Abstract

The presence and distribution of Factor VIII related antigen (FVIIIR:Ag) in formalin fixed, paraffin embedded tissue were studied in benign and malignant vascular tumors, inflammatory vascular diseases, normal tissue from various organs and a number of malignant tumors. The unlabeled peroxidase-anti-peroxidase method was utilized. Immunostaining was observed only in endothelial cells, in tumor cells of endothelial cell origin and in megakaryocytes and platelets. The staining method gave a distinct picture of the vascular pattern in all types of tissue examined. The demonstration of FVIIIR: Ag by means of the immunoperoxidase technique is considered a valuable method in diagnosing tumors of vascular origin. The method also facilitates detection of vascular invasion of malignant tumors in small caliber vessels.

DOI: 10.1007/BF00437598

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@article{Sehested1981FactorVR, title={Factor VIII related antigen as an endothelial cell marker in benign and malignant diseases}, author={Maxwell Sehested and Klaus Hou-Jensen}, journal={Virchows Archiv A}, year={1981}, volume={391}, pages={217-225} }