Factor VIII inhibitors in patients with hemophilia A: epidemiology of inhibitor development and induction of immune tolerance for factor VIII.

@article{Kreuz1995FactorVI,
  title={Factor VIII inhibitors in patients with hemophilia A: epidemiology of inhibitor development and induction of immune tolerance for factor VIII.},
  author={Wolfhart Kreuz and Sabine C. Becker and E. H. Lenz and Inmaculada Mart{\'i}nez-Saguer and C. Escuriola-Ettingshausen and Markus Funk and Silke Ehrenforth and Guenter Auerswald and Bernhard Kornhuber},
  journal={Seminars in thrombosis and hemostasis},
  year={1995},
  volume={21 4},
  pages={382-9}
}
Factor (F) VIII inhibitor development remains one of the most serious complications in the treatment of hemophilia A. Former and recent studies on inhibitor development revealed that patients with severe hemophilia A and positive inhibitor family history are at highest risk of developing an inhibitor. Comparison of recent inhibitor incidence studies on previously untreated patients indicate that the risk of inhibitor development under treatment with recombinant FVIII concentrates is comparable… CONTINUE READING

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