Factor VIII inhibition associated with chlorpromazine-induced hepatic injury.

Abstract

A 90-year-old man was given chlorpromazine for sedation and 2 weeks later developed cholestatic jaundice and subsequently a factor VIII inhibitor. His death 4 weeks after institution of chlorpromazine, from massive bleeding, coupled with the autopsy finding of intrahepatic cholestatic jaundice, suggests that both adverse reactions were due to the drug.

Cite this paper

@article{Glazier1977FactorVI, title={Factor VIII inhibition associated with chlorpromazine-induced hepatic injury.}, author={Rhonda Glazier and Edward B. Crowell}, journal={Thrombosis and haemostasis}, year={1977}, volume={37 3}, pages={523-6} }