Factor VIII-induced superaggregation of human platelets.

  title={Factor VIII-induced superaggregation of human platelets.},
  author={Edward P. Kirby and david. c. mills and Holm Holmsen and Massimo Russo},
  volume={60 6},
High concentrations of bovine factor VIII cause clumping of platelets into a few very large aggregates. This response is termed superaggregation. It is distinct from factor-VIII-induced agglutination but is also independent of both extracellular calcium ions and platelet energy metabolism. Neither agglutinating lectins nor aggregating agents, including… CONTINUE READING