Factor VIII gene polymorphisms in the Asian Indian population.

  title={Factor VIII gene polymorphisms in the Asian Indian population.},
  author={Madhumita Roy Chowdhury and Falko H. Herrmann and W. E. G. Muller H. C. Schroder and Christophe Lambert and Michel R. A. Lalloz and Mark Layton and H. K. Kumbnani and Madhulika Kabra and Puthezhath S N Menon and Ishwar Chandra Verma},
  journal={Haemophilia : the official journal of the World Federation of Hemophilia},
  volume={6 6},
Little is known about the heterozygous frequency of factor VIII gene markers in the Asian Indian population. The objective of this study was to establish the heterozygous frequency of polymorphic markers within and flanking the factor VIII gene in Indians and identify those most informative for carrier screening and prenatal diagnosis. Factor VIII gene polymorphism analysis at intragenic and extragenic sites was carried out by the polymerase chain reaction (PCR) method and Southern blot… CONTINUE READING