Factor VIII C1 domain spikes 2092-2093 and 2158-2159 comprise regions that modulate cofactor function and cellular uptake.

@article{Bloem2013FactorVC,
  title={Factor VIII C1 domain spikes 2092-2093 and 2158-2159 comprise regions that modulate cofactor function and cellular uptake.},
  author={Esther Bloem and Maartje van den Biggelaar and Aleksandra A Wr{\'o}blewska and Jan Voorberg and Johan H. Faber and Marianne Kjalke and Henning Ralf Stennicke and Koen Mertens and Alexander Benjamin Meijer},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 41},
  pages={
          29670-9
        }
}
The C1 domain of factor VIII (FVIII) has been implicated in binding to multiple constituents, including phospholipids, von Willebrand factor, and low-density lipoprotein receptor-related protein (LRP). We have previously described a human monoclonal antibody called KM33 that blocks these interactions as well as cellular uptake by LRP-expressing cells. To unambiguously identify the apparent "hot spot" on FVIII to which this antibody binds, we have employed hydrogen-deuterium exchange mass… CONTINUE READING

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