Factor VII gene polymorphisms contribute about one third of the factor VII level variation in plasma.

@article{Bernardi1996FactorVG,
  title={Factor VII gene polymorphisms contribute about one third of the factor VII level variation in plasma.},
  author={Fabio Bernardi and Giovanna Marchetti and Mirko Pinotti and P. Arcieri and Claudia Baroncini and Maddalena Papacchini and Enrico Zepponi and N Ursicino and Flavia Chiarotti and Guglielmo Mariani},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={1996},
  volume={16 1},
  pages={72-6}
}
To assess the role of genetic variation in determining factor VII (FVII) activity and antigen levels we studied a polymorphism located in the 5' region of the gene (5'F7), an intronic mutation (IVS7), and the 353Arg-Gln polymorphism. All the polymorphisms, which showed strong allelic association, analyzed separately or in combination by the one-way analysis of variance, were associated with significantly different FVII levels. The 5'F7 and 353Arg-Gln polymorphic systems, which have very similar… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 52 extracted citations

Similar Papers

Loading similar papers…