Factor V R506Q Mutation-Leiden: An Independent Risk Factor for Venous Thrombosis but not Coronary Artery Disease

@article{IraniHakime2001FactorVR,
  title={Factor V R506Q Mutation-Leiden: An Independent Risk Factor for Venous Thrombosis but not Coronary Artery Disease},
  author={Noha A. Irani-Hakime and Hala M. Tamim and Ghanem Elias and Salah Choueiry and Raghid Kreidy and Jocelyn L. Daccache and Wassim Youssef Almawi},
  journal={Journal of Thrombosis and Thrombolysis},
  year={2001},
  volume={11},
  pages={111-116}
}
Background: A specific point G-A transition at nucleotide position 1691 in the factor V (FV) gene, FV-Leiden, was associated with increased risk of venous thromboembolism (VTE). Insofar as the association of FV-Leiden with coronary artery disease (CAD) remains poorly defined, the aim of this study was to determine the prevalence of FV-Leiden in a sample of 68 VTE patients, 69 CAD patients, and 192 randomly selected healthy subjects. Methods: Total genomic DNA was extracted from the peripheral… CONTINUE READING
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