Factor V Leiden mutation carriership and venous thromboembolism in polycythemia vera and essential thrombocythemia.

@article{Ruggeri2002FactorVL,
  title={Factor V Leiden mutation carriership and venous thromboembolism in polycythemia vera and essential thrombocythemia.},
  author={Marco Ruggeri and Heinz Gisslinger and Alberto Tosetto and Claudia Rintelen and Christine Mannhalter and Ingrid Pabinger and Navide Heis and Giancarlo Castaman and Edoardo Missiaglia and Klaus Lechner and Francesco Rodeghiero},
  journal={American journal of hematology},
  year={2002},
  volume={71 1},
  pages={1-6}
}
Polycythemia Vera (PV) and Essential Thrombocythemia (ET) are chronic myeloproliferative disorders complicated by a high incidence of thrombotic complications. Extensive coagulation studies failed to demonstrate a consistent pattern of abnormalities associated with thrombosis. Recently, a poor anticoagulant response to activated protein C (APC), due to a mutation of factor V (FV Leiden), has been identified as the most frequent hereditary disorder associated with venous thrombophilia. We… CONTINUE READING