Factor V Leiden (resistance to activated protein C) increases the risk of myocardial infarction in young women.

@article{Rosendaal1997FactorVL,
  title={Factor V Leiden (resistance to activated protein C) increases the risk of myocardial infarction in young women.},
  author={Frits R Rosendaal and David S Siscovick and Stephen M Schwartz and Robert K. Beverly and Bruce M. Psaty and William T. Longstreth and Trivellore E. Raghunathan and Thomas D. Koepsell and Pieter H. Reitsma},
  journal={Blood},
  year={1997},
  volume={89 8},
  pages={2817-21}
}
Factor V Leiden (factor V Arg506Gln), the genetic defect underlying resistance to activated protein C, is the most common risk factor for venous thrombosis. The relationship between this genetic abnormality and arterial disease is still unresolved. To assess whether factor V Leiden increases the risk of myocardial infarction (MI), we conducted a population-based case-control study among women 18 to 44 years of age in western Washington state. We included 84 women with first MI and 388 control… CONTINUE READING