Factor V (Quebec): a bleeding diathesis associated with a qualitative platelet Factor V deficiency.

@article{Tracy1984FactorV,
  title={Factor V (Quebec): a bleeding diathesis associated with a qualitative platelet Factor V deficiency.},
  author={Paula B. Tracy and Alan R. Giles and Kenneth G. Mann and L L Eide and H. Hoogendoorn and Georges Etienne Rivard},
  journal={The Journal of clinical investigation},
  year={1984},
  volume={74 4},
  pages={1221-8}
}
Studies were performed on a French-Canadian family afflicted with a bleeding disorder exhibiting an autosomal dominant inheritance pattern and a severe bleeding diathesis after trauma. Clinical laboratory coagulation tests were unimpressive; the only persistent abnormalities include mild thrombocytopenia and moderately reduced Factor V clotting activities. Some individuals had prolonged Stypven times when platelet-rich plasma was used, suggesting that their platelets could not support… CONTINUE READING

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