Factor IX and thrombosis

@article{Lowe2001FactorIA,
  title={Factor IX and thrombosis},
  author={G. Lowe},
  journal={British Journal of Haematology},
  year={2001},
  volume={115}
}
  • G. Lowe
  • Published 2001
  • Medicine
  • British Journal of Haematology
Coagulation factor IX (FIX) plays an essential role in blood coagulation, as shown by the bleeding tendency associated with congenital FIX deficiency (haemophilia B, Christmas disease). Recent studies show that, after activation of FIX by the tissue factor:FVIIa complex, or by FXIa, FIX plays a key role in thrombin generation in the vicinity of platelets, and that FIXa is the thrombogenic trigger after infusion of prothrombin complex concentrates. Two recent case±control studies have shown that… Expand
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Topics from this paper

Polymorphisms in coagulation factor genes and their impact on arterial and venous thrombosis.
The association between raised coagulation factor levels and venous thrombo-embolism.
Padua FIXa resistance to Protein S and a potential therapy for hyperactive FIXa.
Identification of prothrombin as a major thrombogenic agent in prothrombin complex concentrates
Pathogenesis of venous thromboembolism.
Impact of Thrombogenic Mutations on Clinical Phenotypes of von Willebrand Disease
Factor IX Deficiency
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