Factor H-related protein 1 neutralizes anti-factor H autoantibodies in autoimmune hemolytic uremic syndrome.

@article{Strobel2011FactorHP,
  title={Factor H-related protein 1 neutralizes anti-factor H autoantibodies in autoimmune hemolytic uremic syndrome.},
  author={Stefanie Strobel and Cynthia Abarrategui-Garrido and Elena Fariza-Requejo and Harald Seeberger and Pilar S{\'a}nchez-Corral and Mih{\'a}ly J{\'o}zsi},
  journal={Kidney international},
  year={2011},
  volume={80 4},
  pages={397-404}
}
The autoimmune form of atypical hemolytic uremic syndrome (HUS) is characterized by circulating autoantibodies against the complement regulator factor H, and is often associated with deficiency of the factor H-related proteins CFHR1 and CFHR3. Here we studied whether anti-factor H autoantibodies crossreact with CFHR1, and determined functional consequences of this. In ELISA, anti-factor H immunoglobulin G (IgG) autoantibodies from 24 atypical HUS patients bound to the short consensus repeat 20… CONTINUE READING

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