Factor H binding to bone sialoprotein and osteopontin enables tumor cell evasion of complement-mediated attack.

@article{Fedarko2000FactorHB,
  title={Factor H binding to bone sialoprotein and osteopontin enables tumor cell evasion of complement-mediated attack.},
  author={Neal S. Fedarko and Berthold Fohr and Pamela G Robey and Marian F. Young and Larry Warren Fisher},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 22},
  pages={
          16666-72
        }
}
Metastatic cancer cells, like trophoblasts of the developing placenta, are invasive and must escape immune surveillance to survive. Complement has long been thought to play a significant role in the tumor surveillance mechanism. Bone sialoprotein (BSP) and osteopontin (OPN, ETA-1) are expressed by trophoblasts and are strongly up-regulated by many tumors. Indeed, BSP has been shown to be a positive indicator of the invasive potential of some tumors. In this report, we show that BSP and OPN form… CONTINUE READING

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