Factor Analysis Resolution of the Different RNA Species Induced by pH and Temperature Changes

@inproceedings{Gargallo1997FactorAR,
  title={Factor Analysis Resolution of the Different RNA Species Induced by pH and Temperature Changes},
  author={R. Gargallo and Rom{\`a} Tauler and A. Izquierdo-ridorsa},
  year={1997}
}
The protonation equilibria and conformational changes of a mixture of tyrosine and valine tRNAs were studied by means of spectroscopically monitored acid-base titrations (UV spectrophotometry, circular dichroism and molecular fluorescence) in a working aqueous medium 0.15 M in NaC1 and at 37 °C. Spectroscopic data were analyzed by an Alternating Least Squares (ALS) based multivariate curve resolution procedure which consists of using several chemometrical techniques based on factor analysis… CONTINUE READING