Facing two T cell epitopes: a degree of randomness in the primary response is lost upon secondary immunization.

@article{Bousso2000FacingTT,
  title={Facing two T cell epitopes: a degree of randomness in the primary response is lost upon secondary immunization.},
  author={Philippe Bousso and Fabrice Lema{\^i}tre and Janine Bilsborough and P. Kourilsky},
  journal={Journal of immunology},
  year={2000},
  volume={165 2},
  pages={760-7}
}
We have analyzed the hierarchy of epitope-specific T cell populations during a primary and a secondary CD8 T cell response. MHC-peptide tetramers were used to track the in vivo kinetics of expansion of T cell populations specific for two Kd-restricted epitopes simultaneously presented by a murine tumor cell following primary or recall immunizations. Individual syngeneic mice generated remarkably different primary CTL responses, as reflected by up to 60-fold differences in the relative… CONTINUE READING

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