Facilitatory effect of the dopamine D4 receptor agonist PD168,077 on memory consolidation of an inhibitory avoidance learned response in C57BL/6J mice

  title={Facilitatory effect of the dopamine D4 receptor agonist PD168,077 on memory consolidation of an inhibitory avoidance learned response in C57BL/6J mice},
  author={Pascale Bernaerts and Ezio Tirelli},
  journal={Behavioural Brain Research},
  • P. Bernaerts, E. Tirelli
  • Published 16 June 2003
  • Biology, Psychology, Chemistry, Medicine
  • Behavioural Brain Research

Selective blockade of dopamine D3 versus D2 receptors enhances frontocortical cholinergic transmission and social memory in rats: a parallel neurochemical and behavioural analysis

Selective blockade of D3 receptors facilitates frontocortical cholinergic transmission and improves social memory in rats, and support the pertinence of D 3 receptors as a target for treatment of disorders in which cognitive function is compromised.

PD168077, a D4 receptor agonist, reverses object recognition deficits in rats: potential role for D4 receptor mechanisms in improving cognitive dysfunction in schizophrenia

The results suggest that D4 receptor activation can improve cognitive dysfunction in an animal model relevant to schizophrenia.

Dopamine D4 receptor stimulation contributes to novel object recognition: Relevance to cognitive impairment in schizophrenia

D4 receptor agonism has a beneficial effect on novel object recognition in sub-chronic PCP-treated rats and augments the cognitive enhancing efficacy of an atypical antipsychotic drug that lacks affinity for the D4 receptor, lurasidone.

Effects of activation of D1 dopamine receptors on extinction of a conditioned passive avoidance reflex and amnesia in aggressive and submissive mice

  • N. Dubrovina
  • Biology, Psychology
    Neuroscience and Behavioral Physiology
  • 2006
The studies reported here demonstrate the relationship between the effect of activation of D1 dopamine receptors on the reproduction of a conditioned passive avoidance reflex during extinction and

A-412997, a selective dopamine D4 agonist, improves cognitive performance in rats

The dopamine D3 receptor antagonist, S33138, counters cognitive impairment in a range of rodent and primate procedures.

Although dopamine D(3) receptor antagonists have been shown to enhance frontocortical cholinergic transmission and improve cognitive performance in rodents, data are limited and their effects have

Selective dopamine D4 receptor agonist (A-412997) improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rat

Comparing the effects of a selective D4 receptor agonist, A-412997, with methylphenidate or amphetamine in preclinical models of efficacy versus abuse liability suggests that selective activation of the D4 receptors may represent a target for the treatment of attention deficit hyperactivity disorder without the potential drug abuse liability associated with current psychostimulant therapies.

Effects of Activation and Blockade of Dopamine Receptors on the Extinction of a Passive Avoidance Reaction in Mice with a Depressive-Like State

Learning and extinction of a conditioned passive avoidance reaction resulting from neuropharmacological actions on dopamine D1 and D2 receptors were demonstrated to be specific in intact mice and in



Dose-dependent effects of the dopamine D1 receptor agonists A77636 or SKF81297 on spatial working memory in aged monkeys.

  • J. CaiA. Arnsten
  • Psychology, Biology
    The Journal of pharmacology and experimental therapeutics
  • 1997
The selective dopamine D1 receptor full agonists A77636 and SKF81297 were examined in aged monkeys for effects on the working memory functions of the PFC and the improvement and impairment in performance were reversed by pretreatment with the D1 receptors antagonist, SCH23390.

Selective dopamine D4 receptor antagonists reverse apomorphine-induced blockade of prepulse inhibition

Results suggest that dopamine receptor antagonists with selectivity for the D4 dopamine receptor subtype may be effective in the treatment of schizophrenia, while being less likely to produce dyskinesias associated with D2 receptor antagonists.