Facilitatory actions of serotonin type 3 receptors on GABAergic inhibitory synaptic transmission in the spinal superficial dorsal horn.

@article{Fukushima2009FacilitatoryAO,
  title={Facilitatory actions of serotonin type 3 receptors on GABAergic inhibitory synaptic transmission in the spinal superficial dorsal horn.},
  author={Teruyuki Fukushima and Toshiki Ohtsubo and Masayuki Tsuda and Yuchio Yanagawa and Yuuichi Hori},
  journal={Journal of neurophysiology},
  year={2009},
  volume={102 3},
  pages={1459-71}
}
Analgesic effects of serotonin (5-hydroxytryptamine [5-HT]) type 3 (5-HT3) receptors may involve the release of gamma-aminobutyric acid (GABA) in the spinal dorsal horn. However, the precise synaptic mechanisms for 5-HT3 receptor-mediated spinal analgesia are not clear. In this study, we investigated whether GABAergic neurons in the superficial dorsal horn (SDH) express functional 5-HT3 receptors and how these 5-HT3 receptors affect GABAergic inhibitory synaptic transmission in the SDH, by… CONTINUE READING
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