Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

@article{Levitan1995FacilitationOL,
  title={Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene},
  author={Diane J Levitan and Iva Greenwald},
  journal={Nature},
  year={1995},
  volume={377},
  pages={351-354}
}
THE lin-12 and glp-1 genes of Caenorhabditis elegans are members of the lin-12 / Notch family of receptors for intercellular signals that specify cell fate1,2. By screening for suppressors of a lin-12 gain-of-function mutation, we identified a new gene, sel-12, which appears to function in receiving cells to facilitate signalling mediated by lin-12 and glp-1. The sel-12 gene encodes a protein with multiple transmembrane domains, and is similar to S182, which has been implicated in early-onset… 
SEL-8, a nuclear protein required for LIN-12 and GLP-1 signaling in Caenorhabditis elegans.
TLDR
It is reported that sel- 8 is essential for lin-12- and glp-1-mediated signaling, and that SEL-8 is a glutamine-rich nuclear protein that serves as a transcriptional coactivator or as an assembly factor for transcription complexes that contain the LIN-12 or GLP-1 intracellular domains.
p24 Proteins and Quality Control of LIN-12 and GLP-1 Trafficking in Caenorhabditis elegans
TLDR
A role for SEL-9 and other p24 proteins in the negative regulation of transport of LIN-12 and GLP-1 to the cell surface is suggested, and a role for p 24 proteins in a quality control mechanism for endoplasmic reticulum–Golgi transport is favored.
Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans.
TLDR
The results suggest that SEL-12 does not function downstream of activated LIN-12, and potential parallels for the role of Sel-12/presenilin in facilitating LIN- 12/Notch activity and in amyloid precursor protein (APP) processing are discussed.
SUP-17, a Caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signalling.
TLDR
It is shown that sup-17 encodes a member of the ADAM family of metalloproteases, which functions in Drosophila neurogenesis and the vertebrate ADAM10 protein, and that Sup-17 can act cell autonomously to facilitate lin-12 activity.
sel-7, a Positive Regulator of lin-12 Activity, Encodes a Novel Nuclear Protein in Caenorhabditis elegans
TLDR
It is suggested that sel-7 is a positive regulator of lin-12 activity, and that SEL-7 encodes a novel nuclear protein that forms upon LIN-12 activation.
New Positive Regulators of lin-12 Activity in Caenorhabditis elegans Include the BRE-5/Brainiac Glycosphingolipid Biosynthesis Enzyme
TLDR
Recovery of alleles of six new genes from a screen for suppressors of the egg-laying defect associated with elevated lin-12 activity are described and genetic analysis and cell ablation experiments suggest that bre-5 functions prior to ligand-induced ectodomain shedding that activates LIN-12 for signal transduction.
Evidence for functional and physical association between Caenorhabditis elegans SEL-10, a Cdc4p-related protein, and SEL-12 presenilin.
TLDR
It is shown that loss of sel-10 activity can suppress the egg-laying defective phenotype associated with reducing seL-12 activity, and that Sel-10 can physically complex with SEL-12.
SEL-5, a serine/threonine kinase that facilitates lin-12 activity in Caenorhabditis elegans.
TLDR
It is suggested that sel-5 acts prior to or during ligand-dependent release of the intracellular domain, which can suppress defects in the anchor cell/ventral uterine precursor cell fate decision and a sex myoblast/coelomocyte decision.
The Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome.
TLDR
It is proposed that SEL-10-mediated proteolysis of FEM-1 and FEM3 is required for normal hermaphrodite development, and mutations causing loss-of-function of sel-10 also have masculinizing activity, indicating that seL-10 functions to promote female development.
The Role of the Presenilin-1 Homologue Gene sel-12 ofCaenorhabditis elegans in Apoptotic Activities*
TLDR
The results suggest the similar involvement of PS1-inducing apoptosis under oxidative stress and mitochondrial dysfunction in the Alzheimer's Disease brain.
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