Facilitation of fear extinction by the 5-HT(1A) receptor agonist tandospirone: possible involvement of dopaminergic modulation.

@article{Saito2013FacilitationOF,
  title={Facilitation of fear extinction by the 5-HT(1A) receptor agonist tandospirone: possible involvement of dopaminergic modulation.},
  author={Yasuhiro Saito and Machiko Matsumoto and Yoshiki Yanagawa and Sachiko Hiraide and Sumiyoshi Inoue and Yasunori Kubo and Kei-ichi Shimamura and Hiroko Togashi},
  journal={Synapse},
  year={2013},
  volume={67 4},
  pages={161-70}
}
Fear extinction-based exposure treatment is an important component of psychotherapy for anxiety disorders such as posttraumatic stress disorder (PTSD). Recent studies have focused on pharmacological approaches combined with exposure therapy to augment extinction. In this study, we elucidated the therapeutic potential of the serotonin 1A (5-HT(1A) ) receptor agonist tandospirone compared with the effects of the N-methyl-D-aspartate partial agonist D-cycloserine (DCS), focusing on the possible… CONTINUE READING

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