Facilitation of epinephrine-induced afterdepolarizations by class III antiarrhythmic drugs.

@article{Patterson1997FacilitationOE,
  title={Facilitation of epinephrine-induced afterdepolarizations by class III antiarrhythmic drugs.},
  author={Eugene Patterson and Benjamin J. Scherlag and B. J. Szabo and Ralph Lazzara},
  journal={Journal of electrocardiology},
  year={1997},
  volume={30 3},
  pages={217-24}
}
The electrophysiologic actions of epinephrine (10(-9) M, 10(-8) M, and 10(-7) M) were evaluated in canine Purkinje fibers pretreated with the class III antiarrhythmic drugs clofilium (10(-7) M) or d,l-sotalol (10(-6) M). Clofilium and d,l-sotalol prolonged action potential duration at 50% and 90% of repolarization without provoking early afterdepolarization (EAD) or delayed afterdepolarization (DAD). Subsequent administration of epinephrine provoked both bradycardia-dependent EADs and… CONTINUE READING