Facilitation of emergence of multidrug-resistant state by alteration of tumor environment: implications from competitive ecology models.

@article{Michelson1987FacilitationOE,
  title={Facilitation of emergence of multidrug-resistant state by alteration of tumor environment: implications from competitive ecology models.},
  author={Seth Michelson},
  journal={Cancer treatment reports},
  year={1987},
  volume={71 11},
  pages={1093-4}
}
The presence of multidrug-resistant (MDR) cells in a solid tumor constitutes a major problem in cancer therapy. Current thinking suggests that the resistant phenotype arises de novo during the tumor's evolution via somatic mutation mechanisms. The proportion of MDR cells, once established, may be enriched during therapy as a consequence of differential cell… CONTINUE READING