Facilitation of coronary spasm by propranolol in Prinzmetal's angina: fact or unproven extrapolation?


BACKGROUND Alpha-adrenergic activation enhances coronary vascular tone; beta-blockade leaves alpha-adrenergic vasoconstriction unopposed. Whether beta-adrenergic blockade facilitates coronary spasm in patients with Prinzmetal's angina is unknown. METHODS Using quantitative angiography, we evaluated the response of normal and narrowed coronary arteries to… (More)


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