Facilitation of Feedback Inhibition Through Blockade of Glucocorticoid Receptors in the Hippocampus

@article{Haarst1997FacilitationOF,
  title={Facilitation of Feedback Inhibition Through Blockade of Glucocorticoid Receptors in the Hippocampus},
  author={Aernout D. van Haarst and Melly S. Oitzl and E. Ronald de Kloet},
  journal={Neurochemical Research},
  year={1997},
  volume={22},
  pages={1323-1328}
}
In the present study the effects of intracerebroventricular (icv) and intrahippocampal administration of corticosteroid antagonists on basal hypothalamic-pituitary-adrenal (HPA) activity around the diurnal peak were compared in male Wistar rats. In two separate experiments the glucocorticoid receptor (GR) antagonist RU 38486 and the mineralocorticoid receptor (MR) antagonist RU 28318 were tested. One hour after GR antagonist injection, significant increases in plasma ACTH and corticosterone… CONTINUE READING
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