Facilitation of ECT by intravenous administration of theophylline.

  title={Facilitation of ECT by intravenous administration of theophylline.},
  author={A. F. G. Leentjens and Walter W. van den Broek and Arinardi Kusuma and Jan Antonie Bruijn},
  journal={Convulsive therapy},
  volume={12 4},
Seven patients with major depression who developed seizure inhibition during a course of ECT, were given intravenous theophylline to increase seizure duration. Infusion of 100-200 mg of theophylline, administered slowly over several minutes approximately 30 min before seizure induction, was found to effectively and safely prolong seizure durations. In a total of 55 treatment sessions, no cardiovascular or other complications were seen. On one occasion, seizure duration was prolonged to 220 s.