Facilitation of Ca2+-activated K+ channels (IKCa1) by mibefradil in B lymphocytes

@article{Yoo2007FacilitationOC,
  title={Facilitation of Ca2+-activated K+ channels (IKCa1) by mibefradil in B lymphocytes},
  author={Hae Young Yoo and Haifeng Zheng and Joo Hyun Nam and Yen Lam Hoang Nguyen and Tong Mook Kang and Yung E. Earm and Sung Joon Kim},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={2007},
  volume={456},
  pages={549-560}
}
K+ channels play critical roles in the proliferation and activation of lymphocytes. Mouse B cells express large-conductance background K+ channel (LKbg) in addition to the voltage-gated K+ channel (Kv) and Ca2+-activated K+ channel current (IKCa1). Mibefradil, a blocker of T-type Ca2+ channels, has been reported to affect the proliferation of immune cells. In this study, we investigated the effects of mibefradil on the membrane potential and ion channels in murine B cell lines, WEHI-231 and Bal… CONTINUE READING

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