Facilitation at single synapses probed with optical quantal analysis

  title={Facilitation at single synapses probed with optical quantal analysis},
  author={Thomas G. Oertner and Bernardo L. Sabatini and Esther A. Nimchinsky and Karel Svoboda},
  journal={Nature Neuroscience},
Many synapses can change their strength rapidly in a use-dependent manner, but the mechanisms of such short-term plasticity remain unknown. To understand these mechanisms, measurements of neurotransmitter release at single synapses are required. We probed transmitter release by imaging transient increases in [Ca2+] mediated by synaptic N-methyl-D-aspartate receptors (NMDARs) in individual dendritic spines of CA1 pyramidal neurons in rat brain slices, enabling quantal analysis at single synapses… CONTINUE READING
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