Facilitating cytokine-mediated cancer cell death by proteobacterial N-acylhomoserine lactones.

Abstract

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) preferentially induces apoptosis in cancer cells over normal cells; however, tumor cells may develop TRAIL resistance. Here, we demonstrate that this resistance can be overcome in the presence of bacterial acylhomoserine lactones (AHLs) or AHL-producing bacteria through the combined effect of… (More)
DOI: 10.1021/cb4000184

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