Facilitating clinical implementation of pharmacogenomics.

@article{Mrazek2011FacilitatingCI,
  title={Facilitating clinical implementation of pharmacogenomics.},
  author={David A. Mrazek and Caryn Lerman},
  journal={JAMA},
  year={2011},
  volume={306 3},
  pages={
          304-5
        }
}
Variability in drug response can be explained, in part, by genetic differences among patients. A clear role in drug toxicity and efficacy has been established for some gene-drug combinations, yet implementation of pharmacogenomic tests in clinical practice lags behind this knowledge. The evidence–adoption gap for many pharmacogenomic tests can be addressed in the short term through the development of consensus-based practice guidelines and clinician education. For genetic variants associated… CONTINUE READING

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