Facilitating axon regeneration in the injured CNS by microtubules stabilization.

  title={Facilitating axon regeneration in the injured CNS by microtubules stabilization.},
  author={Vetrivel Sengottuvel and Dietmar Fischer},
  journal={Communicative & integrative biology},
  volume={4 4},
Traumatic CNS injuries often cause permanent, devastating disabilities due to a lack of regeneration of damaged axons. Next to an insufficient intrinsic capability of CNS neurons to regrow axons, also inhibitory molecules that are associated with the CNS myelin and the glial scar contribute to the failure of axonal regeneration. Strategies targeting the inhibitory molecules, their receptors or downstream signaling pathways result in little improvement of regeneration in vivo. However, the… CONTINUE READING


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