Facilitated binding of GAL4 and heat shock factor to nucleosomal templates: differential function of DNA-binding domains.

@article{Taylor1991FacilitatedBO,
  title={Facilitated binding of GAL4 and heat shock factor to nucleosomal templates: differential function of DNA-binding domains.},
  author={I C Taylor and Jerry L. Workman and Thomas J. Schuetz and Robert E. Kingston},
  journal={Genes & development},
  year={1991},
  volume={5 7},
  pages={1285-98}
}
Regulatory factors must contend with chromatin structure to function. Although nucleosome structure and position on promoters can be important in determining factor access, the intrinsic ability of factors to bind to nucleosomal DNA might also play an essential regulatory role. We have used templates where nucleosomes were either randomly positioned or rotationally phased to demonstrate that two transcription factors, heat shock factor (HSF) and GAL4, differ significantly in their ability to… CONTINUE READING

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