Facilitated antigen presentation and its inhibition by blocking IgG antibodies depends on IgE repertoire complexity.

@article{Holm2011FacilitatedAP,
  title={Facilitated antigen presentation and its inhibition by blocking IgG antibodies depends on IgE repertoire complexity.},
  author={Jens Age Holm and Nicholas Willumsen and Peter Adler W{\"u}rtzen and Lars Harder Christensen and Kaare Lund},
  journal={The Journal of allergy and clinical immunology},
  year={2011},
  volume={127 4},
  pages={
          1029-37
        }
}
BACKGROUND The antibody repertoires of allergic subjects are characterized by the presence of allergen-specific IgE antibodies. We have previously shown that the composition of the IgE repertoire is critical for allergen-mediated activation of human effector cells. Activation of CD4(+) T cells in allergic subjects is highly potentiated by the process of facilitated antigen presentation (FAP), in which allergen in complex with IgE is taken up by B cells through the low-affinity IgE receptor CD23… CONTINUE READING
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