Facile synthesis of polyhydroxycoumaronochromones with quinones: synthesis of alkylpolyhydroxy- and alkoxycoumaronochromones from 2′-hydroxyisoflavones

@article{Tsukayama2001FacileSO,
  title={Facile synthesis of polyhydroxycoumaronochromones with quinones: synthesis of alkylpolyhydroxy- and alkoxycoumaronochromones from 2′-hydroxyisoflavones},
  author={M. Tsukayama and A. Oda and Y. Kawamura and M. Nishiuchi and K. Yamashita},
  journal={Tetrahedron Letters},
  year={2001},
  volume={42},
  pages={6163-6166}
}
Abstract 4′,5,7-Trihydroxy- or 8-alkyl-4′,5,7-trihydroxycoumaronochromones were synthesized by oxidative cyclization of the corresponding 2′-hydroxyisoflavones with o -chloranil under mild conditions. By contrast, alkoxycoumaronochromones were synthesized by oxidative cyclization of the corresponding 2′-hydroxyisoflavones with DDQ. 
Constrained phytoestrogens and analogues as ERbeta selective ligands.