Facile synthesis of a high-affinity ligand for mammalian hepatic lectin containing three terminal N-acetylgalactosamine residues.

@article{Lee1997FacileSO,
  title={Facile synthesis of a high-affinity ligand for mammalian hepatic lectin containing three terminal N-acetylgalactosamine residues.},
  author={Reiko T. Lee and Young Choon Lee},
  journal={Bioconjugate chemistry},
  year={1997},
  volume={8 5},
  pages={762-5}
}
A simple cluster glycoside containing three residues of N-acetylgalactosamine with proper inter-residual distances can be a high-affinity ligand for asialoglycoprotein receptor of mammalian liver. YEE(ah-GalNAc)3 [Lee, R. T., and Lee, Y. C. (1987) Glycoconjugate J, 4, 317-328] is such a ligand having a Kd in the subnanomolar range, and this high-affinity… CONTINUE READING