Facile preparation of CF3-substituted carbinols with an azine donor and subsequent kinetic resolution through stereoselective Si-O coupling.

Abstract

A number of CF(3)-substituted carbinols decorated with an azine donor are efficiently prepared from fluoral and kinetically resolved in a reagent-controlled, Cu-H-catalysed Si-O coupling with a chiral silane. Selectivity factors are high, indicating a larger steric effect than CH(3) or C(6)H(5) groups.

DOI: 10.1039/b911534j

Cite this paper

@article{Steves2009FacilePO, title={Facile preparation of CF3-substituted carbinols with an azine donor and subsequent kinetic resolution through stereoselective Si-O coupling.}, author={Anne Steves and Martin Oestreich}, journal={Organic & biomolecular chemistry}, year={2009}, volume={7 21}, pages={4464-9} }