Facile photocyclization chemistry of 5-phenylthio-2'-deoxyuridine in duplex DNA.

@article{Zeng2006FacilePC,
  title={Facile photocyclization chemistry of 5-phenylthio-2'-deoxyuridine in duplex DNA.},
  author={Yu Zeng and Huachuan Cao and Yinsheng Wang},
  journal={Organic letters},
  year={2006},
  volume={8 12},
  pages={2527-30}
}
We report here the synthesis of 5-phenylthio-2'-deoxyuridine (d(PhS)U), its incorporation into oligodeoxynucleotides (ODNs), and its photocyclization chemistry. Irradiation of dinucleoside monophosphate d((PhS)UG) and d(PhS)U-bearing duplex ODNs with 254 nm light results in the facile formation of a cyclic product where the C6 of uracil is covalently bonded… CONTINUE READING