Facile immunotargeting of nanoparticles against tumor antigens using site-specific biotinylated antibody fragments.

@article{Prantner2013FacileIO,
  title={Facile immunotargeting of nanoparticles against tumor antigens using site-specific biotinylated antibody fragments.},
  author={Andrew M Prantner and Calvin Nguyen and Nathalie Scholler},
  journal={Journal of biomedical nanotechnology},
  year={2013},
  volume={9 10},
  pages={1686-97}
}
Nanotechnology is actively being developed for preclinical and clinical oncology applications. Nanoparticle-based immunotargeting against tumor antigens with antibodies or antibody fragments is designed to increase the nanoparticle concentration at the tumor site. However, chemical-based strategies for bioconjugating antibody fragments to nanoparticles typically result in a functionally heterogeneous population of conjugates due to alteration of amino acids within the antigen binding site. The… CONTINUE READING
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