Facile formation of co-amorphous atenolol and hydrochlorothiazide mixtures via cryogenic-milling: Enhanced physical stability, dissolution and pharmacokinetic profile.

@article{Moinuddin2017FacileFO,
  title={Facile formation of co-amorphous atenolol and hydrochlorothiazide mixtures via cryogenic-milling: Enhanced physical stability, dissolution and pharmacokinetic profile.},
  author={Sakib M Moinuddin and Sida Ruan and Yuting Huang and Qin Gao and Qin Shi and Baochang Cai and Ting Cai},
  journal={International journal of pharmaceutics},
  year={2017},
  volume={532 1},
  pages={
          393-400
        }
}
The development of poorly water-soluble drugs faces the risk of low bioavailability and therapeutic efficacy. The co-amorphous drug delivery system has recently gained considerable interest because it offers an alternative approach to modify properties of poorly water-soluble drugs. Herein, we developed a co-amorphous system of atenolol (ATE) and poorly water-soluble hydrochlorothiazide (HCT) by means of cryogenic milling. The co-administration of ATE and HCT has been reported to show… CONTINUE READING

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