Facile detection of mitochondrial DNA mutations in tumors and bodily fluids.

@article{Fliss2000FacileDO,
  title={Facile detection of mitochondrial DNA mutations in tumors and bodily fluids.},
  author={M S Fliss and Henning Usadel and Otavia L. Caballero and Leonard Wu and Mihai Buta and Scott M. Eleff and J Jen and David Sidransky},
  journal={Science},
  year={2000},
  volume={287 5460},
  pages={
          2017-9
        }
}
Examination of human bladder, head and neck, and lung primary tumors revealed a high frequency of mitochondrial DNA (mtDNA) mutations. The majority of these somatic mutations were homoplasmic in nature, indicating that the mutant mtDNA became dominant in tumor cells. The mutated mtDNA was readily detectable in paired bodily fluids from each type of cancer and was 19 to 220 times as abundant as mutated nuclear p53 DNA. By virtue of their clonal nature and high copy number, mitochondrial… CONTINUE READING

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