Facile conversion of chromane-6-triflate to chromane-6-alanines under Palladium conditions.

Abstract

Conversion of chromane-6-triflate 5 to chromane-6-dehydroalanine 9 or 10 via its Bpin-derivative 6 followed by Suzuki coupling with protected dehydroalanine bromides 7 or 8 were reported (86%). Alternatively, a palladium-catalyzed stannation of 5 with Bu6Sn2 afforded the tributyltin derivative 11, and iodination (12) followed by coupling with 13 gave… (More)

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Cite this paper

@article{Miller2013FacileCO, title={Facile conversion of chromane-6-triflate to chromane-6-alanines under Palladium conditions.}, author={Daniel Kyle Miller}, journal={Tetrahedron letters}, year={2013}, volume={54 8}, pages={811-813} }