Facile and rapid one-step radiosynthesis of [(18)F]BAY94-9172 with a new precursor.

@article{Wang2011FacileAR,
  title={Facile and rapid one-step radiosynthesis of [(18)F]BAY94-9172 with a new precursor.},
  author={Hongliang Wang and Hui-Jie Shi and Haiyan Yu and Shende Jiang and Ganghua Tang},
  journal={Nuclear medicine and biology},
  year={2011},
  volume={38 1},
  pages={
          121-7
        }
}
INTRODUCTION [(18)F]BAY94-9172 (Florbetaben) (Compound 8) is a positron emission tomography (PET) tracer that is currently in Phase III study for in vivo mapping of fibrillar amyloid β as a pathological hallmark for Alzheimer's disease. This work reports new methods for the synthesis of [(19)F]BAY94-9172 and its two different precursors and radiosynthesis of [(18)F]BAY94-9172 with the two precursors by purification using Sep-Pak cartridge. METHODS The reference standard [(19)F]BAY94-9172 and… 
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