Facile and convenient method of deuterium gas generation using a Pd/C-catalyzed H2-D2 exchange reaction and its application to synthesis of deuterium-labeled compounds.

@article{Kurita2008FacileAC,
  title={Facile and convenient method of deuterium gas generation using a Pd/C-catalyzed H2-D2 exchange reaction and its application to synthesis of deuterium-labeled compounds.},
  author={Takanori Kurita and Fumiyo Aoki and Takuto Mizumoto and Toshihide Maejima and Hiroyoshi Esaki and Tomohiro Maegawa and Yasunari Monguchi and Hironao Sajiki},
  journal={Chemistry},
  year={2008},
  volume={14 11},
  pages={
          3371-9
        }
}
The Pd/C-catalyzed H(2)-D(2) exchange reaction using a H(2)-D(2)O combination provided a general, efficient and environmentally friendly route for the preparation of deuterium gas (D(2)). H(2) sealed in a reaction flask was converted into nearly pure D(2), which could be used for the Pd/C-catalyzed one-pot reductive deuteration of various reducible functionalities and the chemoselective one-pot deuterogenation of olefin and acetylene. Additionally, we established the capturing method of the… CONTINUE READING
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