Facile Supramolecular Approach to Nucleic-Acid-Driven Activatable Nanotheranostics That Overcome Drawbacks of Photodynamic Therapy.

@article{Li2017FacileSA,
  title={Facile Supramolecular Approach to Nucleic-Acid-Driven Activatable Nanotheranostics That Overcome Drawbacks of Photodynamic Therapy.},
  author={Xingshu Li and Sungsook Yu and Dayoung Lee and Gyoungmi Kim and Buhyun Lee and Yejin Cho and Bi-yuan Zheng and Mei-Rong Ke and Jian-Dong Huang and Ki Taek Nam and Xiaoyuan Chen and Juyoung Yoon},
  journal={ACS nano},
  year={2017},
  volume={12 1},
  pages={
          681-688
        }
}
Supramolecular chemistry provides a "bottom-up" method to fabricate nanostructures for biomedical applications. Herein, we report a facile strategy to directly assemble a phthalocyanine photosensitizer (PcS) with an anticancer drug mitoxantrone (MA) to form uniform nanostructures (PcS-MA), which not only display nanoscale optical properties but also have the capability of undergoing nucleic-acid-responsive disassembly. These supramolecular assemblies possess activatable fluorescence emission… CONTINUE READING
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