Facile Preparation of Core-Shell Magnetic Metal-Organic Framework Nanoparticles for the Selective Capture of Phosphopeptides.

@article{Chen2015FacilePO,
  title={Facile Preparation of Core-Shell Magnetic Metal-Organic Framework Nanoparticles for the Selective Capture of Phosphopeptides.},
  author={Yajing Chen and Zhichao Xiong and Li Peng and Yangyang Gan and Yiman Zhao and Jie Shen and Junhong Qian and Lingyi Zhang and Weibing Zhang},
  journal={ACS applied materials & interfaces},
  year={2015},
  volume={7 30},
  pages={
          16338-47
        }
}
In regard to the phosphoproteome, highly specific and efficient capture of heteroideous kinds of phosphopeptides from intricate biological sample attaches great significance to comprehensive and in-depth phosphorylated proteomics research. However, until now, it has been a challenge. In this study, a new-fashioned porous immobilized metal ion affinity chromatography (IMAC) material was designed and fabricated to promote the selectivity and detection limit for phosphopeptides by covering a metal… CONTINUE READING

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