Facile Generation of Tumor-pH-Labile Linkage-Bridged Block Copolymers for Chemotherapeutic Delivery.

@article{Sun2016FacileGO,
  title={Facile Generation of Tumor-pH-Labile Linkage-Bridged Block Copolymers for Chemotherapeutic Delivery.},
  author={Chun-yang Sun and Yang Liu and Jin-Zhi Du and Zhi-Ting Cao and Cong-Fei Xu and Jun Wang},
  journal={Angewandte Chemie},
  year={2016},
  volume={55 3},
  pages={1010-4}
}
Successful bench-to-bedside translation of nanomedicine relies heavily on the development of nanocarriers with superior therapeutic efficacy and high biocompatibility. However, the optimal strategy for improving one aspect often conflicts with the other. Herein, we report a tactic of designing tumor-pH-labile linkage-bridged copolymers of clinically validated poly(D,L-lactide) and poly(ethylene glycol) (PEG-Dlink(m)-PDLLA) for safe and effective drug delivery. Upon arriving at the tumor site… CONTINUE READING
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